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Title: Mt-th  
Author: World Heritage Encyclopedia
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Subject: Human mitochondrial genetics, MELAS syndrome, MERRF syndrome
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mitochondrially encoded tRNA histidine
Symbol MT-TH
Alt. symbols MTTH
Entrez HUGO OMIM RefSeq Locus [1]

Mitochondrially encoded tRNA histidine, also known as MT-TH, is a transfer RNA which, in humans, is encoded by the mitochondrial MT-TH gene.[1]


MT-TH is a small 69 nucleotide RNA (human mitochondrial map position 12138-12206) that transfers the amino acid histidine to a growing polypeptide at the ribosomal site of protein synthesis during translation.

Clinical significance

MT-TH is associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).[2][3]

It has also been associated with MERRF syndrome.[2]


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