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Cox Proportional Hazards Models for Modeling the Time to Onset of Decompression Sickness in Hypobaric Environments: by Laura A. Thompson

By Thompson, Laura A.

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Title: Cox Proportional Hazards Models for Modeling the Time to Onset of Decompression Sickness in Hypobaric Environments: by Laura A. Thompson  
Author: Thompson, Laura A.
Volume:
Language: English
Subject: Government publications, National Aeronautics and Space Administration (U.S.), NASA reference publication
Collections: NASA Publication Collection
Historic
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Publisher: National Aeronautics and Space Administration Publication

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A, T. L. (n.d.). Cox Proportional Hazards Models for Modeling the Time to Onset of Decompression Sickness in Hypobaric Environments. Retrieved from http://worldlibrary.org/


Excerpt
Excerpt: Since its founding, NASA has been dedicated to the advancement of aeronautics and space science. The NASA Scientific and Technical Information (STI) Program Office plays a key part in helping NASA maintain this important role. The NASA STI Program Office is operated by Langley Research Center, the lead center for NASA?s scientific and technical information. The NASA STI Program Office provides access to the NASA STI Database, the largest collection of aeronautical and space science STI in the world. The Program Office is also NASA?s institutional mechanism for disseminating the results of its research and development activities. These results are published by NASA in the NASA STI Report Series, which includes the following report types...

Table of Contents
Contents Abstract ................................................................................................................................................ 1 1. Introduction ................................................................................................................................ 1 2. Cox Proportional Hazards Model.................................................................................................. 2 2.1 Stratified Cox Models........................................................................................................ 3 3. Description of Data ...................................................................................................................... 3 3.1 Exploratory Analysis ......................................................................................................... 5 4. Assessment of Proportional Hazards............................................................................................. 8 4.1 Initial Fit of a Cox PH Model ............................................................................................. 9 4.2 Test of Time-varying Coefficients in a Cox PH Model ....................................................... 10 4.3 Graphical Tests for PH After Fitting a Cox Model .............................................................. 14 5. Stratified Cox Proportional Hazards Model................................................................................... 16 5.1 Fit of Stratified Cox Proportional Hazards Models ............................................................. 16 5.2 Test of PH Assumption for Stratified Cox Models: Test for Time-varying Coefficients....... 17 5.3 Graphical Tests for PH After Fitting a Stratified Cox Model............................................... 19 5.4 Expected Survival from a Stratified Cox Model.................................................................. 20 5.5 Lack of Fit in the Stratified Cox Model .............................................................................. 21 5.5.1 Deviance Residuals and Normal Deviate Residuals for Assessing Poorly Predicted Individuals ................................................................................. 21 5.5.2 Global Goodness-of-Fit Using Martingale Residuals ............................................. 24 5.5.3 Assessment of Influential Observations................................................................. 25 6. Interpretation of the Stratified Cox Model..................................................................................... 29 7. Discussion On the Use of Frailty Models for DCS Data ................................................................ 30 8. Model Validation ......................................................................................................................... 32 8.1 Predictive Accuracy of Cox Models ................................................................................... 33 8.2 Model Calibration of Survival Predictions.......................................................................... 34 9. Concluding Remarks.................................................................................................................... 35 Appendix ? Arjas Plots.......................................................................................................................... 36 References ............................................................................................................................................ 37

 

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