World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : a Re-emerging Marker for Prognosis in Hepatocellular Carcinoma ; the Add-value of Fishing C-myc Gene for Early Relapse, Volume 8

By W.I. Lo, Anthony

Click here to view

Book Id: WPLBN0003943039
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : a Re-emerging Marker for Prognosis in Hepatocellular Carcinoma ; the Add-value of Fishing C-myc Gene for Early Relapse, Volume 8  
Author: W.I. Lo, Anthony
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collection: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos

Description : Hepatocellular carcinoma is one leading cause of cancer-related death and surgical resection is still one of the major curative therapies. Recently, there has been a major effort to find mechanisms involved in carcinogenesis and early relapse. c-myc gene abnormality is found in hepatocarcinogenesis. Our aim was to analyze the role of c-myc as prognostic factor in terms of overall survival and disease-free survival and to investigate if c-myc may be an important target for therapy. We studied sixty-five hepatocellular carcinomas submitted to surgical resection with curative intent. Size, macro-microvascular invasion, necrosis, number of nodules, grading and serum alfa-fetoprotein level were registered for all cases. We evaluated the c-myc aberrations by using break-apart FISH probes. Probes specific for the centromeric part of chromosome 8 and for the locus specific c-myc gene (8q24) were used to assess disomy, gains of chromosomes (polysomy due to polyploidy) and amplification. c-myc gene amplification was scored as 8q24/ CEP8 > 2. Statistical analysis for disease-free survival and overall survival were performed. At molecular level, c-myc was amplified in 19% of hepatocellular carcinoma, whereas showed gains in 55% and set wild in 26% of cases. The 1- and 3-year disease-free survival and overall survival for disomic, polysomic and amplified groups were significantly different (p=0.020 and p=.018 respectively). Multivariate analysis verified that the AFP and c-myc status (amplified vs. not amplified) were significant prognostic factors for overall patients survival. c-myc gene amplification is significantly correlated with disease-free survival and overall survival in patients with hepatocellular carcinoma after surgical resection and this model identifies patients with risk of early relapse (≤12 months). We suggest that c-myc assessment may be introduced in the clinical practice for improving prognostication (high and low risk of relapse) routinely and may have be proposed as biomarker of efficacy to anti-c-myc targeted drugs in clinical trials.


Click To View

Additional Books

  • Plos One : Differential Expression of Pr... (by )
  • Plos One : Thioredoxin-1 Attenuates Earl... (by )
  • Plos One : Grape Powder Intake Prevents ... (by )
  • Plos One : Chemoirradiation for Glioblas... (by )
  • Plos One : an Efficient Weighted Graph S... (by )
  • Plos One : Transposable Elements in Tdp-... (by )
  • Plos One : Regulation of Cell Wall Synth... (by )
  • Plos One : Biogeographical Boundaries, F... (by )
  • Plos One : Impairment of Ifn-gamma Respo... (by )
  • Plos One : Somatosensory Profiles but No... (by )
  • Plos One : Suppression of Induced Micror... (by )
  • Plos One : Trpa1 Mediates Mechanical Sen... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.