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Plos One : Brap2 Regulates Temporal Control of Nf-ҡb Localization Mediated by Inflammatory Response, Volume 8

By Srinivasula, M.

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Book Id: WPLBN0003944720
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Brap2 Regulates Temporal Control of Nf-ҡb Localization Mediated by Inflammatory Response, Volume 8  
Author: Srinivasula, M.
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos

Description : Nuclear factor-kappaB (NF-kB) is critical for the expression of multiple genes involved in inflammatory responses and cellular survival. NF-kB is normally sequestered in the cytoplasm through interaction with an inhibitor of NF-kB (IkB), but inflammatory stimulation induces proteasomal degradation of IkB, followed by NF-kB nuclear translocation. The degradation of IkB is mediated by a SCF (Skp1-Cullin1-F-box protein)-type ubiquitin ligase complex that is posttranslationaly modified by a ubiquitin-like molecule Nedd8. In this study, we report that BRCA1-associated protein 2 (Brap2) is a novel Nedd8-binding protein that interacts with SCF complex, and is involved in NF-kB translocation following TNF-a stimulation. We also found a putative neddylation site in Brap2 associated with NF-kB activity. Our findings suggest that Brap2 is a novel modulator that associates with SCF complex and controls TNF-a-induced NF-kB nuclear translocation.


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